Goodpasture Syndrome/Pathology
Pulmonary hemorrhage and glomerulonephritis are features in most patients with this disease.
Autoantibodies to renal glomerular and lung alveolar basement membranes are present.
[This syndrome can present and recur as DAH without an associated glomerulonephritis. In such cases, circulating anti-basement membrane antibody is often absent, and the only way to establish the diagnosis is by demonstrating linear immunofluorescence in lung tissue.]
High magnification micrograph showing a crescentic glomerulonephritis, also known as a rapidly progressive glomerulonephritis. PAS stain. Kidney biopsy. Immunofluorescence demonstrated linear staining with IgG, characteristic of anti-glomerular basement membrane disease, also known as Goodpasture syndrome.1 https://en.wikipedia.org/wiki/Goodpasture_syndrome#/media/File:Crescentic_glomerulonephritis_-_high_mag.jpg
HISTOLOGIC FINDINGS
The underlying histology may be bland hemorrhage or DAH associated with capillaritis.
It involves an autoimmune disorder. Normally, the immune system makes antibodies to fight off germs. But with Goodpasture syndrome, the immune system mistakenly makes antibodies that attack the lungs and kidneys. This condition can quickly progress to an inflammation of the kidneys (glomerulonephritis) and kidney failure. It can be fatal if not quickly diagnosed and treated.
small vessel vasculitis that affects glomerular capillaries, pulmonary capillaries, or both. Most patients present with rapidly progressive (crescentic) glomerulonephritis, although some patients may present with relatively mild kidney impairment. In general, this disorder is typically associated with severe kidney injury that, if untreated, progresses quickly to end-stage kidney disease (ESKD).